Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 172 | 现货 | ||
5 mg | ¥ 378 | 现货 | ||
10 mg | ¥ 622 | 现货 | ||
25 mg | ¥ 825 | 现货 | ||
50 mg | ¥ 1,080 | 现货 | ||
100 mg | ¥ 1,830 | 现货 | ||
200 mg | ¥ 2,720 | 现货 | ||
500 mg | ¥ 4,460 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 496 | 现货 |
产品描述 | Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. |
体内活性 | Six female Persian onagers (Equus hemionus onager) were treated with fluphenazine decanoate (FD;?0.1?mg/kg IM) or saline control in a random crossover design study.?Urinary cortisol, progesterone, estrogen metabolites and behavior were monitored, and follicular dynamics were examined using ultrasonography until ovulation.?Onagers demonstrated significantly lower cortisol concentrations (P?=?0.03) when treated with FD (6.61?±?3.26?ng/mg creatinine) compared to saline (9.73?±?3.19?ng/mg creatinine).?Overall, there were no differences in peak estrogen (P?=?0.51) or progesterone (P?=?0.38) concentrations between the two groups, and all animals ovulated within the expected time frame following FD treatment.?However, some onagers exhibited only minor reductions in cortisol secretion and one treated female demonstrated a suppressed luteal progesterone peak, indicating a possible reproductive cost to FD administration[1]. |
分子量 | 591.77 |
分子式 | C32H44F3N3O2S |
CAS No. | 5002-47-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (211.23 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6898 mL | 8.4492 mL | 16.8985 mL | 42.2461 mL |
5 mM | 0.338 mL | 1.6898 mL | 3.3797 mL | 8.4492 mL | |
10 mM | 0.169 mL | 0.8449 mL | 1.6898 mL | 4.2246 mL | |
20 mM | 0.0845 mL | 0.4225 mL | 0.8449 mL | 2.1123 mL | |
50 mM | 0.0338 mL | 0.169 mL | 0.338 mL | 0.8449 mL | |
100 mM | 0.0169 mL | 0.0845 mL | 0.169 mL | 0.4225 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Fluphenazine decanoate 5002-47-1 GPCR/G Protein Neuroscience Dopamine Receptor hypothalamic tyrosine hydroxylase levels gonadotropin suppression phenothiazine T. gondii Inhibitor reproductive mouth movements hyperprolactinemia neuroleptic inhibit dopamine-D2 human tardive dyskinesia antifertility serum prolactin schizophrenia long-acting jaw tremor vacuous chewing mouth movement inhibitor